There are many good points here, however, for me the biggest benefit is that with the big guys I typically make more money, so while the pay may take longer to arrive, it is typically a much larger check.
I also focus on larger clients because they have more volume. I write for a company that hires me to write 4 articles per month at $225 for 800 words. I have chatted on the phone with the manager one time and they just send me monthly outlines. With my smaller clients it can be harder and require more communication because they really need each article to count.
In the end I think they are both focusing on different strategies. Big businesses are looking to get volume of keywords in articles to rank highly, where as smaller companies use articles in a more direct sales type of way.